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Increased Susceptibility to Postoperative PCA Morphine-Induced Respiratory Depression in a Patient with an Undiagnosed Traumatic Porencephalic Cyst – A Case Report

Cristina Petrișor1,2, Sebastian Trancă1,2, Andreea Cordoș2,3, Vasile Bințințan2,3

1 Anesthesia and Intensive Care II Department, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania
2 Clinical Emergency County Hospital Cluj-Napoca, Romania
3 Surgery Department I, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania

DOI: 10.2478/jccm-2019-0011

Introduction: Patient-controlled analgesia with morphine is routinely used for postoperative pain management. Due to the safety profiles of the technique, which are patient/disease related or technique/equipment related, severe respiratory depression requiring opioid antagonists or airway management are uncommon.
Case presentation: The case of a patient with right colon carcinoma who was operated on for hemicolectomy under general anaesthesia and who presented with apnoea, after postoperatively receiving an initial bolus of 1mg of morphine. A large post-traumatic porencephalic cyst of the left brain hemisphere, previously undiagnosed, was found on the computed tomography scan. We excluded human errors, technique and equipment factors, and the patient did not have any other predisposing conditions like sleep apnoea, obesity, recent head injury or concurrent use of other sedatives. Previously the patient had been entirely asymptomatic, and her increased susceptibility to respiratory depression was the only clinical manifestation of porencephaly.
Conclusion: Adult acquired porencephaly is seldom reported in the literature, clinical manifestations depending on the location and size of the cyst. In the present reported case, increased susceptibility to low-dose opioids might be associated with the structural and functional reorganisation of the brain after head trauma with the occurrence of the porencephalic cyst of the brain.

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Refractory Lactic Acidosis and an Approach to Its Management – A Case Report

Yingke He1, John Ong2, Sharon Ong3

1 Division of Anaesthesiology, Singapore General Hospital, Singapore
2 Department of Engineering, Materials Engineering and Material-Tissue Interactions Group, University of Cambridge, United Kingdom
3 Department of Surgical Intensive Care, Singapore General Hospital, Singapore

DOI: 10.2478/jccm-2019-0010

Background: Lactic acidosis (LA) is a complication of diseases commonly seen in intensive care patients which carries an increased risk of mortality. It is classified by its pathophysiology; Type A results from tissue hypo-perfusion and hypoxia, and Type B results from abnormal metabolic activity in the absence of hypoxia. Reports of the co-occurrence of both types have been rarely reported in the literature relating to intensive care patients. This case report describes the challenging management of a patient diagnosed with both Type A and Type B LA.
Case presentation: A 55-year-old female with newly diagnosed diffuse large B-cell lymphoma (DLBCL) developed hospital-acquired pneumonia, respiratory failure, shock and intra-abdominal septicaemia from a bowel perforation. Blood gases revealed a mixed picture lactic acidosis. Correction of septic shock, respiratory failure and surgical repair caused initial improvement to the lactic acidosis, but this gradually worsened in the intensive care unit. Only upon starting chemotherapy and renal replacement therapy was full resolution of the lactic acidosis achieved. The patient was discharged but succumbed to her DLBCL several months later.
Conclusion: Type A and Type B LA can co-occur, making management difficult. A systematic approach can help diagnose any underlying pathology and aid in early management.

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Pulseless Electrical Activity Arrest as the First Symptom of Testicular Cancer with Subsequent Phlegmasia Cerulea Dolens

Shane Belvedere

Department of Vascular Surgery, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria, Australia

DOI: 10.2478/jccm-2019-0009

Introduction: Phlegmasia cerulea dolens (PCD) is a severe, rare complication of deep vein thrombosis, which is characterised by compartment syndrome, arterial compromise, venous gangrene, and shock. Prothrombotic states are the primary risk factor for PCD, which, in most cases, is associated with pulmonary embolism and carries a high mortality.
Case report: A 46-year-old male presented following a pulseless electrical activity (PEA) arrest due to saddle pulmonary embolism (PE). He subsequently developed PCD and venous gangrene secondary to inferior vena cava obstruction, in the setting of a new diagnosis of testicular germ cell tumour.
Discussion: PEA arrest, as the initial presenting problem in malignancy, is rare. It is extreme for the first indication of cancer to be a PEA arrest from massive PE. While hypoxic brain injury from the cardiac arrest precluded intervention in this case, a surgical approach entailing en bloc resection of aortocaval metastasis, with subsequent IVC reconstruction, followed by lower limb venous thrombectomy would have been favoured as it was considered that an endovascular approach would not have been successful.
Conclusion: A case of a patient with phlegmasia cerulea dolens secondary to testicular cancer, who presented following PEA arrest is described.

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Opportunities for Practices in Precision Population Health and Personalized Medicine

William W. Au1

1 University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania; Shantou University Medical College, Shantou, China; and University of Texas Medical Branch, Galveston, Texas, USA

DOI: 10.2478/jccm-2019-0006

During the previous decades, the practice of cancer prevention and intervention has achieved much success at the population level. However, it has become obvious that such achievements at the individual levels have been highly variable and, perhaps, disappointing. Therefore, to significantly improve efficacy, the United States and the European Union have set up priority programs on the development of precision population health and personalized medicine. The emphasis will require a paradigm shift in focusing these activities onto individuals instead of populations. In addition, it changes our traditional approach in conducting basic research and clinical medicine, e.g. by incorporating more genomic information and more personal data into research and practice activities. [More]

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Sepsis in Acute Mediastinitis – A Severe Complication after Oesophageal Perforations. A Review of the Literature

Mircea Mureșan1, Simona Mureșan2, Ioan Balmoș1, Daniela Sala1, Bogdan Suciu3, Arpad Torok1

1 University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Surgery Clinic No.2
2 University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Physiology Department
3 University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Thoracic Surgery Department

DOI: 10.2478/jccm-2019-0008

Background. Despite recent advancements in antibiotic therapy and the progress made in critical care and modern diagnostic methods, acute mediastinitis continues to be a severe condition.
Diagnosis and treatment. Acute mediastinitis can occur in the context of cardio-thoracic surgery, oesophageal perforations and oropharyngeal infections condition. Forty-five percent of oesophageal perforations occurs during simple endoscopy. Spontaneous perforation (Boerhaave syndrome) accounts for 15% of perforations, and twelve percent are due to the ingestion of foreign bodies. Other causes include blind or penetrating trauma, and circa 9% to intraoperative lesions. CT scan is the standard investigation that reveals direct signs of mediastinitis. The oral administration of contrast substances can underscore the level of oesophageal perforation. Conservative treatment is the first-choice treatment and surgical treatment is reserved only for specific situations. The principles of surgical treatment consist of drainage, primary suture, oesophageal exclusion with or without the application of oesophagectomy, endoscopic vacuum wound assisted therapy of the perforation and associated paraoesophageal mediastinal drainage and endoscopic stenting associated with drainage.
Conclusions. The lowest mortality rate is recorded in patients with perforations diagnosed less than twenty-four hours after the onset of symptoms. Surgical treatment remains the gold standard especially in cases of thoracic and abdominal perforations while further investigations are mandatory before endoscopic stenting is carried out.

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Spotlight on How to Structure a Case Report

Ario Santini1

1 University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania; Hon Fellow, University of Edinburgh, United Kingdom

DOI: 10.2478/jccm-2019-0007

This is the first paper in the occasional series which aims to aid and facilitate internists and colleagues who have little or no experience in writing and submitting manuscripts for publication.
Case reports have a very low level of evidence, but they do have a place in medical publications. Polymyalgia rheumatica (PMR) was first established as a distinct disease in 1966 following the publication of a case report on 11 patients. [ Davison S, Spiera H, Plotz CM “Polymyalgia rheumatica”. Arthritis and Rheumatism. 9 (1): 18–23.] [More]

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The Symbiotic Relationship between Authors, Medical Journals, Editors and the Peer Review System

Ario Santini1, 2, Leonard Azamfirei3, Cosmin Moldovan4

1 University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
2 Hon Fellow, University of Edinburgh, United Kingdom
3 Department of Anesthesia and Intensive Care, University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
4 Department of Simulation Applied to Medicine, University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania

DOI: 10.2478/jccm-2019-0005

There is a complex relationship between potential authors, especially those with limited experience in submitting manuscripts, medical journals, editors and the reviewers who participate in the peer review system. There is growing pressure on young graduates undertaking PhD and Master programs to publish papers, as the regulations for the completion of these degrees from many universities require papers to be published before the awarding of these degrees. The pressure to publish is nonetheless high, as colleagues proceed through their career pathway, with publications often dictating successful advancement or promotion. This paper highlights this complex relationship and discusses the responsibilities of all stakeholders, both ethically and professionally. [More]

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Hypercalcaemic Crisis Due to Primary Hyperparathyroidism: Report of Two Cases

Tatiana Daniela Sala1,2, Simona Mureşan3, Ramona Roman1, Alexandra Lazăr1,4, Răzvan Ion2, Ionela Paşcanu1,5

1 University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania
2 Emergency Mures County Hospital, Surgery Clinic no.2, Târgu Mureş, Romania
3 Physiology Department, University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania
4 Anesthesiology and Intensive Care Clinic no. 1, Târgu Mureş, Romania
5 Endocrinology Clinic, Târgu Mureş, Romania

DOI: 10.2478/jccm-2019-0004

Introduction: A hypercalcaemic crisis, also called para thyrotoxicosis, hyper parathyroid crisis or parathyroid storm, is a complication of primary hyperparathyroidism (PHPT) and an endocrinology emergency that can have dramatic or even fatal consequences if it is not recognised and treated in time.
Case presentation: Two cases presented in the emergency department with critical hypercalcaemic symptoms and severe elevation of serum calcium and parathyroid hormone levels, consistent with a hypercalcaemic crisis. The first case, a 16-year-old female patient, had imaging data that highlighted a single right inferior parathyroid adenoma and a targeted surgical approach was used. The second case, a 35-year-old man was admitted for abdominal pain, poor appetite, nausea, and vomiting. Laboratory tests revealed severe hypercalcemia, hypophosphatemia, and an increased serum iPth level. There was no correlation between scintigraphy and ultrasonography, and a bilateral exploration of the neck was preferred, resulting in the exposure of two parathyroid adenomas. The patients were referred for surgery and recovery in both cases was uneventful
Conclusion: These cases support the evidence that surgery remains the best approach for patients with a hypercalcaemic crisis of hyperparathyroidism origin, ensuring the rapid improvement of both the symptomatology and biochemical alterations of this critical disease.

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